Direct Flights and Connections to Top Destinations There’s never been a better time to fly for business or pleasure, with the Springfield Region hosting direct flights to a number of major hub cities, and connections to some of the hottest vacation spots in the country and more. With connectivity to major cities, international travel is simple, making Springfield a great starting point for anyone wanting to expand their global horizons or visit friends and loved ones overseas.So what airlines fly out of Springfield mo? The Springfield-Branson National Airport offers 13 non-stop destinations from four airlines: Allegiant: Los Angeles, Las Vegas, Orlando, Phoenix, Tampa/St. Petersburg, Ft. Myers, Destin/Ft. Walton BeachAmerican: Charlotte, Chicago, Dallas/Ft. WorthDelta: AtlantaUnited: Chicago, Denver, Houston And just down Highway 65 from Springfield, the Branson Airport features direct flights to Austin, Chicago, Houston, New Orleans and Denver from Via Air, Silver Airways and Frontier Airlines. With such great transportation and easy access to anywhere you want to go, more and more travel lovers are discovering that the Springfield Region is one of the best places to come back home to!